RSD 1235 hydrochloride

Name	VERNAKALANT HYDROCHLORIDE
Synonyms	D06665 Vernakalant HCl RSD1235 hydrochloride RSD 1235 hydrochloride RSD-1235 hydrochloride VERNAKALANT HYDROCHLORIDE Vernakalant hydrochloride (usan) Vernakalant ((3R,1'R,2'R)-Isomer) HCl
CAS	748810-28-8

Molecular Formula	C20H32ClNO4
Molar Mass	385.93
Melting Point	151-153oC
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Pale Yellow
Storage Condition	Hygroscopic, Refrigerator, under inert atmosphere
In vitro study	Block of Kv1.5 by Vernakalant Hydrochloride is mediated after channel activation, because Vernakalant causes a relatively rapid onset of block of channel current upon depolarization but little evidence of resting or “tonic” block of the channel. In the presence of 10 μM Vernakalant, rapid block is apparent after channel opening, and a steady-state current level is rapidly reached. The most important effect is the reduction in potency for Vernakalant centered at I502A, which had an IC 50 of 329±19 μM (n=4-10), compared with a control IC 50 of 13.4±0.9 μM (n=5-23), which is a 25-fold decrease in potency. V505A, I508A, T480A, and C500A showed lesser reductions in potency on Kv1.5, of between 3- and 4-fold. I508Y in our experiments increased the IC 50 for Vernakalant on Kv1.5 to 24.7 μM, again similar to the reported value for hERG.

Last Update：2024-01-02 23:10:35

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Product Name: VERNAKALANT HYDROCHLORIDE Visit Supplier Webpage Request for quotation
CAS: 748810-28-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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RSD 1235 hydrochloride

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